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2008a ),bronchopleural and broncho-oesophageal ? stulae(Goussard et al.
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Theadministration of exogenous surfactants in infantswith RDS is effective to prevent the combinedrisk of death and BPD, but generally not the riskof BPD alone (Soll 2000 , 2010).
(3) Instruc-tions to prevent constipation includes a high-fiber dietand 2 to 3 L of fluid a day to promote regular bowelmovements. b.The initial responseto the injury produces a fracture hematoma that surrounds the ends ofthe fractured bone.The ends of bone fragments undergo necrosis.The acuteinflammatory reaction develops and is manifested by infiltration ofneutrophils and macrophages, activation offibroblasts, and proliferation ofcapillar-ies.Thefracture hematoma is gradually replaced by granulation tissue, c.As granulation tissue becomes older,fibrocartilage matrix isbeing deposited.Newly formed fibrocartilage fills the gap at the fracture site producing a soft callus.This stabilizes and binds together the fractured ends of the bone,d. Hu B et al (2006) MDMX overexpression prevents p53 activation by the MDM2 inhibitorNutlin.
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